CLARITY: A Big Advancement For Neuroscience

CLARITY: A Big Advancement For Neuroscience

 

Three-dimensional view of stained hippocampus showing fluorescent-expressing neurons (green), connecting interneurons (red) and supporting glia (blue). Image from Deisseroth lab.

Using fluorescent antibodies that are known to seek out and attach themselves only to specific proteins, Deisseroth’s team showed that it can target specific structures within the CLARITY-modified — or “clarified” — mouse brain and make those structures and only those structures light up under illumination. The researchers can trace neural circuits through the entire brain or explore deeply into the nuances of local circuit wiring. They can see the relationships between cells and investigate subcellular structures. They can even look at chemical relationships of protein complexes, nucleic acids and neurotransmitters.

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