Are digital c.elegans coming soon? Their entire genome has been mapped and a virtual connectome has been published, now can we simulate the entire biology of the worm or worms with different mutations? Alexis Madrigral discusses this topic in a provoking article in The Atlantic:
…What’s so hard about simulating its behavior?
We don’t know how to simulate every single protein and nucleic acid in a cell. And even if we could, it would be computationally staggering to try to model each and every cell in the worm down to that atomic level, figuring out each and every molecular interaction inside these densely packed cells. No experiments can output that data.
Over 150 Neuroscientists met this week to begin planning for the massive BRAIN (Brain Research through Advancing Innovative Neurotechnologies) research initiative.
CLARITY: A Big Advancement For Neuroscience
Three-dimensional view of stained hippocampus showing fluorescent-expressing neurons (green), connecting interneurons (red) and supporting glia (blue). Image from Deisseroth lab.
Using fluorescent antibodies that are known to seek out and attach themselves only to specific proteins, Deisseroth’s team showed that it can target specific structures within the CLARITY-modified — or “clarified” — mouse brain and make those structures and only those structures light up under illumination. The researchers can trace neural circuits through the entire brain or explore deeply into the nuances of local circuit wiring. They can see the relationships between cells and investigate subcellular structures. They can even look at chemical relationships of protein complexes, nucleic acids and neurotransmitters.
Great talk by Korean novelist Young-ha Kim on the value of art and play.
The Cell: An Image Library: Eyes and optic tectum of five-day-old zebrafish larva that has a mutation causing retinal axons to project into the olfactory lobe. This image was created from a 125-slice Z-stack that was collected using 20x magnification. Honorable Mention, 2011 Olympus BioScapes Digital Imaging Competition®.
The beta version of ResumeUp is now available and I thought I would check it out. You can easily sign in with your LinkedIn or Facebook account. Overall the site is user-friendly, but there are limitations when making a selection under the professional area. For one, I was a nontraditional student: I was a competitive ice-dancer, then worked in the art business for a few years before going back to college to finish my degree in my late twenties. At college I was exposed to top neuroscience research and developed a passion for the field. I took on a number of internships and worked while I was school. Now I would like to apply my research skills in the workplace. This could possibly cross over into more than one industry. The ResumeUp application is good for a linear outlook, but I’m wondering how it will be viewed by recruiters if someone did not take a linear career path or alternatively has a portfolio career.
Image of Tali Sharot. Neuroscientist and author of The Optimism Bias: A Tour of the Irrationally Positive Brain.
Brains and beauty gets recognition. Check out the 50 sexy scientists in Business Insider.